Iron, Free Radicals, and Oxidative Injury

Iron, free radicals, and oxidative injury.

Iron metabolism and superoxide metabolism are clearly interactive, especially under pathological conditions. Each can exacerbate the toxicity of the other. Iron overload may amplify the damaging effects of superoxide overproduction in a very broad spectrum of inflammatory or ischemia-related conditions. Furthermore, chronic oxidative stress may modulate iron uptake and storage, leading to a sel...

Free radicals and tissue injury -

Iron regulation by hepatocytes and free radicals

Iron is an essential metallic microelement for life. However, iron overload is toxic. The liver serves an important role as a storehouse for iron in the body. About 20-25 mg of iron is required each day for hemoglobin synthesis. To maintain iron homeostasis, transferrin and transferrin receptors are primarily involved in the uptake of iron into hepatocytes, ferritin in its storage, and ferropor...

Exercise, free radicals and oxidative stress.

This article reviews the role of free radicals in causing oxidative stress during exercise. High intensity exercise induces oxidative stress and although there is no evidence that this affects sporting performance in the short term, it may have longer term health consequences. The mechanisms of exercise-induced oxidative stress are not well understood. Mitochondria are sometimes considered to b...

free radicals and antioxidants “oxidative stress” in cadmium exposure workers

oxidative stress arises when there is a marked imbalance between the production and removal of reactive oxygen species that may lead to several diseases. cadmium is an environmental and industrial pollutant that results in formation of free radicals. the aim of this study was to determine the oxidative stress status in cadmium exposure workers. this is a cross-sectional study of 36 people of ca...